Cytotoxicity of two self-adhesive resin cements and their interference in the phagocytic activity of murine macrophages
da Silva Danilo Couto, Vaz Leonardo Gomes, Tavares Warley Luciano Fonseca, Vieira Leda Quercia, de Oliveira Ricardo Reis, Sobrinho Antonio Paulino Ribeiro,
소속 상세정보
( da Silva Danilo Couto ) - Universidade Federal de Minas Gerais Faculty of Dentistry Department of Restorative Dentistry
( Vaz Leonardo Gomes ) - Universidade Federal de Minas Gerais Institute of Biological Sciences Department of Biochemistry and Immunology
( Tavares Warley Luciano Fonseca ) - Universidade Federal de Minas Gerais Faculty of Dentistry Department of Restorative Dentistry
( Vieira Leda Quercia ) - Universidade Federal de Minas Gerais Institute of Biological Sciences Department of Biochemistry and Immunology
( de Oliveira Ricardo Reis ) - Universidade Federal de Minas Gerais Faculty of Dentistry Department of Restorative Dentistry
( Sobrinho Antonio Paulino Ribeiro ) - Universidade Federal de Minas Gerais Faculty of Dentistry Department of Restorative Dentistry
Abstract
Objectives: This study aimed to evaluate in vitro the effects of the self-adhesive resin cements RelyX U200 (3M ESPE) and seT PP (SDI Limited) on murine macrophages and the interference of the photoactivation.
Materials and Methods: Cell viability assays, cell adherence, yeast phagocytosis of Saccharomyces boulardii and production of reactive oxygen species (ROS) were performed in the presence of capillaries containing the respective self-adhesive cement when photoactivated or not.
Results: After long periods of contact, both types of cements, when not photoactivated, are more cytotoxic for macrophages. The seT PP cement when only chemically activated seems to interfere more negatively in the process of phagocytosis of yeasts S. boulardii. Both types of cements interfere in the cell adhesion process, independent of photoactivation. None of the types of cements tested was able to induce the production of ROS.
Conclusions: Our results highlight the great importance of the photoactivation of self-adhesive resin cements in the dental clinic, since RelyX U200, when photoactivated, presented the best results within the evaluated parameters.
키워드
Cytotoxicity; Macrophages; Dental cement; Resin cement
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